By Katherine Kozlowski (Medical Writer and Contributor to Vein News and VeinsVeinsVens.com)
What is the prevalence of the most common thrombophlia mutations ?
The most common thrombophilic disorder is the heterozygous factor V Leiden mutation, occurring in approximately 5% of pateints of northern European descent.
The prevalence of prothrombin gene mutation ranges from 0 to 4.7% of asymptomatic individuals.
Deficiencies of protein C and S are found in <1% of asymptomatic individuals.
Nicholson M, Chan N, Bhagirath V and Ginsberg J. Prevention of Venous Thromboembolism in 2020 and Beyond. J CLin Med 2020; 9(8): 2467.
Dr Karamanoukian's comment: patients who have had recurrent episodes of deep vein throbosis are considered for genetic testing on a case by case basis. These genetic tests are ordered after consultation with a hematologist.