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Researchers from Serbia completed a literature review to determine possible correlation between various climatic factors and the pathogenesis of deep vein thrombosis.

Colder temperatures stimulate changes in blood cell composition which could cause development of inflammation or a hyper coagulable state.

Results are as follows:

Seasonal changes and DVT Incidence:

• 4 out of 11 studies assessing seasonal patterns in DVT incidence found no relationship.
• 4 out of 11 studies found DVT incidence was higher in Winter.
• One Italian study found that DVT peak was during the months of September-October.

Temperature changes and DVT Incidence:

• Chung et al conducted a study in 17 countries which showed that there was no correlation between temperature change of 5 degrees Celsius and DVT incidence.

• Marcer et al conducted an experimental study exposing volunteers to cold temperatures and found increased hemoconcentrations by increased red blood cells and certain granulocytes.

• Kawahara et al also conducted an experiment exposing volunteers to cold temperatures and found increased platelet activity (clotting cells in the blood) which could be a risk factor for DVT incidence.

Results are inconsistent to determine a direct correlation between temperature changes and DVT incidence; however, exposure to cold temperatures does show hematologic changes that could potentially lead to increased risk of DVT. Further research is warranted. Prospective studies in the future would help determine thrombotic factors that change in humans with climate that contribute to DVT risk.

Reference: Damnjanovic Z, Jovanovic M, Stojanovic M. Correlation between the climatic factors and the pathogenesis of deep vein thrombosis. Hippokratia 2013; 17(3): 203-206.